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About Glaucoma
allergic conjunctivitis: the eye's reaction to allergy-causing substances like pollen and dander. Allergic conjunctivitis symptoms may include redness, tearing, and itching.7

aqueous humor: a transparent fluid occupying the front and rear chambers of the eye, nourishing the lens and cornea.8

chronic: a condition that persists for a long time and generally does not easily or quickly go away.8

contraindication: a condition that renders the use of a remedy or a procedure inadvisable, usually because of risk.8

drainage channel: also known as the drainage angle, where fluid flows from the eye; if these channels are blocked, high eye pressure can result.8

glaucoma: a group of eye conditions characterized by progressive damage to the optic nerve that may lead to gradual loss of vision.8

intraocular pressure (IOP): the pressure created by the continual renewal of fluids within the eye.8

laser surgery [for glaucoma]: laser surgery that involves either laser treatment or making a cut in the eye to reduce the intraocular pressure (IOP). The type of surgery your doctor recommends will depend on the type and severity of your glaucoma and the general health of your eye. Surgery can help lower pressure when medication is not sufficient; however, it cannot reverse vision loss.9

nearsighted: able to see near things more clearly than distant ones.8

ocular hypertension: an increase in the pressure in your eyes that is above the range considered normal, with no detectable changes in vision or damage to the structure of your eyes. The term is used to distinguish people with high pressure from those with glaucoma, an eye disease that causes damage to the optic nerve and vision loss.10

open-angle glaucoma: occurs when the aqueous (fluid) in the eye cannot get through a filtration system called the trabecular meshwork into the drainage canals, causing pressure to build up within the eye, which can damage the optic nerve and impair vision; open-angle glaucoma is the most common form
of glaucoma.8

optic nerve: a bundle of more than 1 million nerve fibers that connects the retina to the brain.3

surgery [for glaucoma]: surgery makes a new opening for the fluid to leave the eye. Your doctor may suggest this treatment at any time. Surgery often is done after medicines and laser surgery have failed to control pressure.3

visual acuity: how well you see at various distances.3

visual field: the entire area that can be seen at a given instant without moving
the eyes.8

INDICATIONS AND USAGE
ALPHAGAN® P (brimonidine tartrate ophthalmic solution) 0.1% or 0.15% is an alpha-adrenergic receptor agonist indicated for the reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension.

IMPORTANT SAFETY INFORMATION

CONTRAINDICATIONS
Neonates and Infants (under the age of 2 years): ALPHAGAN® P is contraindicated in neonates and infants (under the age of 2 years).
Hypersensitivity Reactions: ALPHAGAN® P is contraindicated in patients who have exhibited a hypersensitivity reaction to any component of this medication in the past.
See more below.

INDICATIONS AND USAGE
ALPHAGAN® P (brimonidine tartrate ophthalmic solution) 0.1% or 0.15% is an alpha-adrenergic receptor agonist indicated for the reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension.

IMPORTANT SAFETY INFORMATION

CONTRAINDICATIONS
Neonates and Infants (under the age of 2 years): ALPHAGAN® P is contraindicated in neonates and infants (under the age of 2 years).
Hypersensitivity Reactions: ALPHAGAN® P is contraindicated in patients who have exhibited a hypersensitivity reaction to any component of this medication in the past.

WARNINGS AND PRECAUTIONS
Potentiation of Vascular Insufficiency: ALPHAGAN® P may potentiate syndromes associated with vascular insufficiency. ALPHAGAN® P should be used with caution in patients with depression, cerebral or coronary insufficiency, Raynaud's phenomenon, orthostatic hypotension, or thromboangiitis obliterans.
Severe Cardiovascular Disease: Although brimonidine tartrate ophthalmic solution had minimal effect on the blood pressure of patients in clinical studies, caution should be exercised in treating patients with severe cardiovascular disease.
Contamination of Topical Ophthalmic Products After Use: There have been reports of bacterial keratitis associated with the use of multiple-dose containers of topical ophthalmic products. These containers had been inadvertently contaminated by patients who, in most cases, had a concurrent corneal disease or a disruption of the ocular epithelial surface.

DRUG INTERACTIONS
Antihypertensives/Cardiac Glycosides: Because ALPHAGAN® P may reduce blood pressure, caution in using drugs such as antihypertensives and/or cardiac glycosides with ALPHAGAN® P is advised.
CNS Depressants: Although specific drug interaction studies have not been conducted with ALPHAGAN® P, the possibility of an additive or potentiating effect with CNS depressants (alcohol, barbiturates, opiates, sedatives, or anesthetics) should be considered.
Tricyclic Antidepressants: Tricyclic antidepressants have been reported to blunt the hypotensive effect of systemic clonidine. It is not known whether the concurrent use of these agents with ALPHAGAN® P in humans can lead to resulting interference with the IOP-lowering effect. Caution is advised in patients taking tricyclic antidepressants, which can affect the metabolism and uptake of circulating amines.
Monoamine Oxidase Inhibitors: Monoamine oxidase (MAO) inhibitors may theoretically interfere with the metabolism of brimonidine and potentially result in an increased systemic side effect such as hypotension. Caution is advised in patients taking MAO inhibitors, which can affect the metabolism and uptake of circulating amines.

ADVERSE REACTIONS
Adverse reactions occurring in approximately 10% to 20% of the subjects receiving brimonidine ophthalmic solution (0.1% to 0.2%) included: allergic conjunctivitis, conjunctival hyperemia, and eye pruritus. Adverse reactions occurring in approximately 5% to 9% included: burning sensation, conjunctival folliculosis, hypertension, ocular allergic reaction, oral dryness, and visual disturbance.

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